Cheminformatic Analysis and Machine Learning Modeling to Investigate Androgen Receptor Antagonists to Combat Prostate Cancer.

Therefore, it has become a highly significant therapeutic target for the drug discovery against PCa. 6 , 7 AR has 919 amino acid residues and consists of three major domains: N-terminal domain (NTD) (residues 1–555), DNA binding domain (DBD) (residues 555–623), and the C-terminal ligand binding domain (LBD) (residues 665–919), which is connected to the DBD by a flexible hinge region (residues 623–665).

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