Age Associations with Dry Eye Clinical Signs and Symptoms in the Dry Eye Assessment and Management (DREAM) Study.

For example, in a study of 140 volunteers (70 men and 70 women) with no ocular symptoms or ocular surface disorders, Ozdemir et al 29 found a significant decrease in tear break-up time (TBUT) with increasing age across the 7 decades spanning 11 to 86 years of age, with an especially highly significant difference between the younger and older decades.

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