Novel genetically engineered H3.3G34R model reveals cooperation with ATRX loss in upregulation of <i>Hoxa</i> cluster genes and promotion of neuronal lineage.

Neurooncol Adv · 2023 · PMC9950856 · PMID 36845293

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did not quite reach statistical significanceno p-value reported

Differential gene expression analysis revealed an upregulation of Hoxa2 , Hoxa4 , and Hoxa5 in ATRX KO H3.3G34R relative to ATRX KO H3.3WT tumors though the difference did not quite reach statistical significance.

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