Bioactive PEEK: Surface Enrichment of Vitronectin-Derived Adhesive Peptides.

Furthermore, HVP and D2HVP functionalization significantly enhanced the gene expression of Sox9 at one day from cell seeding, and although it induced a down-regulation of Runx2 at one day, this is inverted at days 7 and 14, suggesting a positive trend over time (for HVP only).

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The graphs about Alp and Oct expression (that are respectively early and late mineralization activity markers) have opposite dynamics: Alp was up-regulated in the first time points by the presence of peptides, and then it decreased at the late days, while Oct showed an increasing trend up to the greatest significant improvements in the gene expression at day 21 ( Figure 9 d) for peptide-enriched surfaces with respect to control. 4.

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