Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs).

Cells · 2023 · PMC9953961 · PMID 36831265

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This difference was highly significant in PB32-ENU condition with a generation of blast cells with cytological features of monoblasts ( Figure 2 C), whereas hematopoietic cells from non-mutagenized cells exhibited a persistent differentiation with the presence of metamyelocytes and polynuclear neutrophils.

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