Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis.

The percentage of potential T-cell responses achieved in each category revealed a nonsignificant trend toward higher responses among ACPA + RA patients to the created peptides (33%) than to no change (17%; P = 0.2918) and destroyed (13%; P = 0.1692) peptide groups, in addition to significantly more frequent responses among ACPA + RA patients to the created peptides (33%) than observed for the controls by χ 2 test (2.5%; P = 0.0002; Fig. 6b ).

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