Barely Significant
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Clinical Characteristics and Outcomes of Patients with Acute Respiratory Failure Due to SARS-CoV-2 Interstitial Pneumonia Treated with CPAP in a Medical Intermediate Care Setting: A Retrospective Observational Study on Comparison of Four Waves.

J Clin Med · 2023 · PMC9959438 · PMID 36836094

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a decreasing trendno p-value reported
In our study, considering lymphocytes’ count, CRP and ferritin, a decreasing trend in the inflammatory burden has been noted from the first to the fourth wave, while vital signs, blood gases, NEWS and SOFA upon admission were comparable throughout all four waves.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.