Cloning and Characterization of <i>Trypanosoma congolense</i> and <i>T. vivax</i> Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis.

Standard resazurin-based drug sensitivity assays showed that as expected, TbAT1 expression caused a highly significant sensitization to tubercidin ( p < 0.0001) in three independent clones ( Figure 10 ), as tubercidin is a good substrate of TbAT1/P2 [ 46 ] but at best a poor substrate for the T. congolense adenosine transporter, TcoAT1 ( Table 6 ) and as a result tubercidin is a relatively poor agent against T. congolense ( Table 8 ). 2.4.4.

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