The Relationship between Iron and LRRK2 in a 6-OHDA-Induced Parkinson's Disease Model.

Int J Mol Sci · 2023 · PMC9964371 · PMID 36835121

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Pathogenic mutations cause highly significant alteration in kinase activity of LRRK2, including the most common mutation of PD, G2019S, which consistently induces 2 to 3-fold increases in kinase activity, resulting in neuronal toxicity [ 10 ].

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