Pre-Diabetes-Linked miRNA miR-193b-3p Targets PPARGC1A, Disrupts Metabolic Gene Expression Profile and Increases Lipid Accumulation in Hepatocytes: Relevance for MAFLD.

At hyperglycemia (20 mM glucose) we observed a significant increase in total area covered by lipid droplets ( Figure 2 G) and number of lipid droplets ( Figure 2 H); we also saw an increasing trend in lipid droplet size ( Figure 2 I), though not statistically significant.

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However, when hsa-miR-193b-3p was overexpressed, we observed a decreasing trend in SLC2A2 /GLUT2 expression, suggesting lower glucose uptake, which may contribute to hyperglycemia, a feature associated with the plasma increase in hsa-miR-193b-3p in humans.

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