Genome-Wide Gene-Set Analysis Identifies Molecular Mechanisms Associated with ALS.

Int J Mol Sci · 2023 · PMC9966913 · PMID 36835433

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The third most highly significant gene set of the GS-GWAS analysis, PID RhoA (Ras homolog gene family member A) pathway (FDR = 0.022), which is primarily linked to the cytoskeleton and to cell-signaling processes, has also been associated with prion-related neurodegeneration [ 68 ].

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