highly significantp = 1.33 × 10 −15
Three highly significant pathways were identified by the Reactome analysis of these protein clusters: The citrate (TCA) cycle pathway ( p = 1.33 × 10 −15 and FDR = 3.46 × 10 −14 ), the mRNA metabolism/catabolism pathway ( p = 7.96 × 10 −8 and FDR = 3.60 × 10 −6 ), and the unfolded protein response pathway (UPR; p = 2.04 × 10 −13 and FDR = 1.35 × 10 −11 ) ( Figure 9 d). 3.3.