Barely Significant
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The Idiosyncratic Efficacy of Spironolactone-Loaded PLGA Nanoparticles Against Murine Intestinal Schistosomiasis.

Int J Nanomedicine · 2023 · PMC9968784 · PMID 36860210

Europe PMCDOI
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highly significantno p-value reported
The authors found that PLGA NPs improved the antischistosomal effects of PZQ with highly significant reduction in mean total worm burden, the highest elevation of the percentage of dead ova (95.31%), with complete disappearance of immature ova and the highest reduction of egg load in hepatic tissue by 97.1%. 76 Another team work 77 potentiate the antischistosomal abilities of the synthetic preparation (the −6,60-dinitrohinokinin (DNHK)) by incorporation to PLGA nanoparticles.

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