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Systemic lupus erythematosus is causally associated with hypothyroidism, but not hyperthyroidism: A Mendelian randomization study.

Front Immunol · 2023 · PMC9968792 · PMID 36860870

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an increasing trendno p-value reported
Overall, the prevalence and mortality have shown an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.