4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism.

Although not significant, 4-F-PCP and KET treatment reduced EAAT3 expression in the PFC of mice compared with mice treated with saline; however, a decreasing trend in EAAT4 was only observed with 4-F-PCP treatment. 4-F-PCP rescues the reduced expression of proteins implicated in synaptic plasticity and major depressive disorder.

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No significant difference was observed in p-TrkB levels, but an increasing trend was observed following treatment with 4-F-PCP and KET.

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