Although this difference did not quite reach statistical significance in this experiment ( P = 0.09), the finding was confirmed in a separate experiment where boosting with MAPS2 further reduced lung CFU by 3-fold compared to BCG vaccination alone ( P < 0.0001) ( Fig.
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A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis.
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