Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase.

Overall, the combined pathology scores of rMERS-CoV MA-DUBneg -vaccinated animals were generally lower than for mock-vaccinated animals (Supplementary Fig 5B ) and the difference between the means of both groups was statistically highly significant ( P <0.001, unpaired, two-tailed Student’s t test).

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