Genomic and transcriptomic analyses identify a prognostic gene signature and predict response to therapy in pleural and peritoneal mesothelioma.

However, notably, even after explicitly controlling for prior treatment time in the Cox regression model, the increased expression in all 48 genes in the mesothelioma prognostic signature is still markedly associated with worse patient survival (Fisher’s exact test for enrichment of overlapping genes between explicitly controlling or not controlling of prior treatment is extremely significant, odds ratio = infinity, p = 1.54e−103).

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