Celastrol-regulated gut microbiota and bile acid metabolism alleviate hepatocellular carcinoma proliferation by regulating the interaction between FXR and RXRα <i>in vivo</i> and <i>in vitro</i>.

Front Pharmacol · 2023 · PMC9975715 · PMID 36874033

Europe PMC DOI

hedged sentence

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closest p · 0.0× alpha

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highly significantp < 0.001actually significant

extremely significantno p-value reported

p -values <0.05 were considered statistically significant at p < 0.01 as highly significant and p < 0.001 as extremely significant. 3 Results 3.1 Celastrol alleviates HCC in an orthotopic HCC rat model We constructed a rat model with orthotopic HCC by treating the rats with DEN and administrated the model rats with celastrol or normal saline in gavage for 10 weeks.

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