Dr.Nod: computational framework for discovery of regulatory non-coding drivers in tissue-matched distal regulatory elements.

When repeating the same analysis with different CADD cut-off values, we observed an increasing trend between the CADD cut-off and the log 2 fold-enrichment of CDGs in the targets of the non-coding regulatory driver candidates (Pearson correlation r = 0.9, P = 6 × 10 −4 ; Figure 2D , Supplementary Figures S2 and S15 ).

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