Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension.

We then compared this pulmonary endothelial cell PAH network with the previously described human PAH disease module inclusive of 357 genes ( 19 , 23 , 24 ) and found a highly significant overlap between these 2 networks ( P < 1.04 × 10 –9 ) ( Supplemental Figure 3D ) as well as between the pulmonary endothelial in inflammatory PAH with other inflammatory (positive control) diseases in the human interactome ( Supplemental Table 2 ).

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