Objective response to immune checkpoint inhibitor therapy in <i>NRAS</i>-mutant melanoma: A systematic review and meta-analysis.

Front Med (Lausanne) · 2023 · PMC9979544 · PMID 36873887

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

not quite statistically significantp = 0.051so close (0.05 < p ≤ 0.1)

30%, though it was not quite statistically significant ( p = 0.051).

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failed to reach significanceno p-value reported

conducted a separate analysis which found higher PD-L1 expression in NRAS -mutant melanoma, though this failed to reach significance and other larger cohorts have not found PD-L1 expression to necessarily be consequential to ICI response ( 16 , 48 ).

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on the borderline of significanceno p-value reported

The trim-and-fill method imputed two moderate-to-large studies, one with a non-significant negative effect size, the other on the borderline of significance, and the Egger regression test was statisticallysignificant for asymmetry ( p = 0.02).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.