Expression pattern of secretory-cell-related transcriptional signatures in colon adenocarcinomas defines tumor microenvironment characteristics and correlates with clinical outcomes.

Correspondingly, there were also highly significant positive correlations between the PCA score of enteroendocrine cell and subtype 2 goblet cell signatures and the activation level of stromal‐related pathways, including epithelial–mesenchymal transition (EMT) and TGFβ signaling (Fig. 1A , right).

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