The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding.

Differences in the nucleoplasmic to peripheral LAC-Ig1 labeling were not quite statistically significant ( p = 0.06) between the high and low cell density and overall lower than those of the individual immunofluorescence intensity values (Fig.

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Although showing a slight trend toward reduced labeling at the highest cell density, the LAC-N antibody did not exhibited any significant changes in immunolabeling across different seeding densities ( Figure 6(b )), suggesting that cell density primarily affects antibody recognition of the Ig-fold epitope.

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