Relationship between <i>MAN2B1</i> genotype/subcellular localization subgroups, antidrug antibody detection, and long-term velmanase alfa treatment outcomes in patients with alpha-mannosidosis.

For the total population, there was a positive trend towards improvement in 6MWT at 12 months ( n = 31; mean change: 21.9 meters [ p = 0.07]; mean percent change: 7.3% [ p = 0.09]), and the improvement was statistically significant at last observation ( n = 33). 17 6MWT was further evaluated by ADA status (Figure 6 B).

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