Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation.

Between-treatment differences remained highly significant at the 24-hour time point regardless of baseline WHO/ECOG performance status (performance status ≤2: 0.87 vs 17.79 hours; P < 0.0001; performance status >2: 1.46 vs >24 hours; P < 0.0001) ( Figure 2 B).

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