Deficiency of the RNA-binding protein ELAVL1/HuR leads to the failure of endogenous and exogenous neuroprotection of retinal ganglion cells.

We correlated the RGC count with PhNR amplitudes to evaluate whether the morphological changes accompany RGC function, and we found a highly significant association ( p = 0.0075, r = −0.8, Pearson’s correlation coefficient, Figure 4E ). 3.3.2. hur silencing alleviates the neuroprotective properties of MT in a rat glaucoma model The rat glaucoma model was induced by thermocoagulation of episcleral and limbal vessels at weeks “0” and “4” to ensure a significant increase in IOP for an 8-week period ( Figure 5A ).

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