Barely Significant
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Global, regional, and national burden of multiple sclerosis from 1990 to 2019: Findings of global burden of disease study 2019.

Front Public Health · 2023 · PMC9982151 · PMID 36875359

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an increasing trendno p-value reported
Regarding period effect, the risk value in the death rate and DALYs had an increasing trend over time, while the incidence rate had a relatively small period effect.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.