Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

Genome Biol · 2023 · PMC9983171 · PMID 36869380

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In the naive state, genes near sites that lost H3K27ac showed highly significant downregulation whether or not they also lost H3K4me1 (States 1,15).

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