Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.

Using this approach, we can demonstrate a highly significant linear correlation ( R 2 = 0.8879) between the predicted ability of each cell line to activate JNK and the observed JNK phosphorylation measured by Western blotting in response to a saturating concentration of vincristine, at the peak time point of activation (300 nM; 2 hours).

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