Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing.

Genome Med · 2023 · PMC9985263 · PMID 36869384

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a slightly increasing trendno p-value reported

Although memory B cells in general decreased following combined treatment, the FCRL4+FCRL5+ B cells (B4_FCRL4), defined as “atypical memory B cells” [ 62 ], exhibited a slightly increasing trend in MPR patients (Fig. 4 B).

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an increasing trendno p-value reported

However, both the M1 signature and M1-like subset (Macro_CXCL9) did not exhibit an increasing trend in MPR patients, and even decreased after therapy (Fig. 6 A, C).

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