An implantable cardioverter-defibrillator for primary prevention in non-ischemic cardiomyopathy: A systematic review and meta-analysis.

Cardiol J · 2023 · PMC9987540 · PMID 33843044

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

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boldest claim

The sentences

borderline significancep = 0.06so close (0.05 < p ≤ 0.1)

Primary endpoint The meta-analysis of pooled hazard ratios in all trials, including a total of 1789 patients, showed that all-cause mortality in the ICD group decreased with borderline significance (167 of 886 patients, i.e. 19%) in comparison to optimal pharmacological treatment (195 of 895 patients, i.e. 22%), with a HR of 0.48 (95% CI 0.67–0.10); p = 0.06; heterogeneity p = 0.78; I 2 = 0% ( Fig. 2 ).

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