Inhalable aerosol microparticles with low carrier dosage and high fine particle fraction prepared by spray-freeze-drying.

Int J Pharm X · 2023 · PMC9988654 · PMID 36896094

Europe PMC DOI

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a decreasing trendno p-value reported

1 (P3, P4, P5, and P6)) showed a decreasing trend, which illustrated that the use of the oil phase as a pore-former in the SFD process to prepare low-density microparticles did not improve the FPF as expected.

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an increasing trendno p-value reported

However, the FPFs of MF were31.48%, 34.24%, 36.93%, and 41.94%, showing an increasing trend, indicating that increasing the number of carrier microparticles could increase the FPF of MF.

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