Rare Dysfunctional <i>Complement Factor I</i> Genetic Variants and Progression to Advanced Age-Related Macular Degeneration.

For progression to NV, a similar effect of BMI for type 1 carriers versus noncarriers was not seen: the effect of BMI among carriers was not significant (OR = 0.6; 95% CI = 0.2, 1.9; P = 0.33), whereas it was borderline significant among noncarriers (OR = 1.2; 95% CI = 1.0, 1.4; P = 0.05).

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There was a nonsignificant trend toward a positive effect of type 1 CFI rare variant status on higher rate of progression to GA for all 3 GRS tertiles, so no significant difference in risk conferred by type 1 CFI rare variant status according to GRS was observed.

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