Altered glutamate-glutamine and amide proton transfer-weighted values in the hippocampus of patients with amnestic mild cognitive impairment: A novel combined imaging diagnostic marker.

Only a few researchers focused on hippocampal Glx levels in patients with MCI (Rupsingh et al., 2011 ; Huang et al., 2017 ; Wong et al., 2020 ) with diverse results: one 7T MRS study with 33 participants demonstrated decreased left hippocampal Glu in patients with MCI (Wong et al., 2020 ), a 3T MRS study with 21 MCI patients showed a decreasing trend of Glx without significant difference in the right hippocampus (Huang et al., 2017 ), and finally, a 4T MRS study with 12 MCI showed no obvious changes of Glu in the right hippocampus (Rupsingh et al., 2011 ).

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