Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy.

Nat Commun · 2023 · PMC9998625 · PMID 36894566

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an increasing trendno p-value reported

Although we did not observe a significant difference in DCA levels, there was an increasing trend, which might cause more damage to the liver and promote ICP development.

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a decreasing trendno p-value reported

We observed a decreasing trend in CDCA levels in the small intestine of B. fragilis -colonized mice, which might further contribute to the reduced intestinal FXR signaling.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.