Protein kinase C mediates hypoxia-induced long-term potentiation of NMDA neurotransmission in the visual retinocollicular pathway.

Front Cell Neurosci · 2023 · PMC9998674 · PMID 36909286

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We observed that hypoxia-induced LTP is associated with a rapid, irreversible and statistically extremely significant shortening of evoked PSCs – the decrease in current decay time constants ( Figure 2D ; control 39.7 ± 2.6 ms; hypoxia 16.7 ± 2.0 ms; reoxygenation 16.4 ± 2.5 ms; t = 85.6, df = 296, p < 0.0001 – hypoxia compare to control; t = 103.2, df = 897, p < 0.0001 – reoxygenation compare to control).

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