Excerpts

Overall, these highly significant (p < 0.0001) associations between epithelial and stromal marker proteins KRT19, CDH1, VCAN, and FAP with LMD-enriched tumor epithelium and stroma, respectively, were observed using the proteomic data from the additional 9 HGSOC cases assessed ( Figure 3 B).

However, as expected, CST was a highly significant predictor of community composition (R 2 = 0.81, p < 0.0001).

The primary patient-derived xenografts used for this study displayed a wide range of tumor hypoxia (1%–39%) that was highly significant ( p < 0.0001), whereas there was relatively little variance in the levels of hypoxia within replicates from the same model ( Figure 1 A).

Linear regression of seasonal curve shape against methodological score was highly significant ( r 2 = 0.3, F = 16.9, P < 0.0001, test for normality = 0.2, P < 0.0001) confirming that the tendency to demonstrate seasonal dynamics between the different retained studies depends largely on the degree of statistical or mathematical technical Sophistication of the study.

Area under the curve (c-statistic) was 0.98, which was highly significant (p<0.0001).

4c , Table S6 , we still detected a similar highly significant lower number of Cav1.3 mRNA molecules (~35%) in SN DA neurons from aged donors (manual: adult 32 ± 2, aged 17 ± 3; N = 3, n = 180; p < 0.0001; DLAP-2: adult 32 ± 3, aged 20 ± 3; N = 3, n = 244; p < 0.0001).

anesthesiologic ICUs there was a highly significant difference between anesthesiologic ICUs compared with other disciplines ( p < 0.0001).

This is a highly significant difference compared to metagenomes from individuals from other countries from which bacteroidetocin B was detected in 1.9–6% of metagenomes ( P < 0.0001).

There was a highly significant linear correlation between the pore density of B. spissa and B. subadvena from Peru, Costa Rica, and Sagami Bay (R 2 = 0.93, p < 0.0001, Fig. 4 b).

Focusing on MCC of the skin ( N = 19,020), the overall proportion of MCC among skin cancers showed an increasing trend over the years ( P < .0001).

Screening for dysphagia as well as brain imaging also exhibited a positive trend (trend p < .0001 and p = 0.09, respectively), both items did not reach the required threshold within the study time (Fig. 2 : a, c).

Even with this drawback, the frequency of heterozygosis and T-alleles was very high and extremely significant when compared with the Ecuadorian control population (P = 0.0001).

The second validation step performed by MS-qPCR on core biopsies from 131, 59 and 36 patients with histologically diagnosed PCa, BPH and high-grade PIN, respectively, showed highly significant differences in the methylation status of the APC, TACC2, RARB, DGKZ, C5orf4 and HES5 regions between BPH and PCa ( P <0.0001).

Subsequent validation revealed a highly significant positive correlation ( r = 0.91; p < 0.0001) between RNA-seq and RT-qPCR results indicating a high reliability of the RNA-seq data.

A response surface analysis shows both MCPNN and MNPR have highly significant effects ( P < 0.0001) on DDTH [DDTH = 1475.34 + (147.92*MCPNN) - (148512.8*MNPR)], explaining 77.54% of the variation (Figure 2 ).

The difference between CD and DH patient groups upon inhibition with TGe was highly significant ( P < 0.0001; Fig. 4 ).

MAS and FMA scores also showed highly significant intergroup differences (p < 0.0001), indicating greater reduction in spasticity and improvement in voluntary motor control with the combined approach.

In addition, a highly significant association ( p <0.0001) was observed between weight gain and the number of cigarette-free days.

The impact of the respondents' perception of local professional norms regarding disclosure on their attitudes and behaviours was substantially highly significant (p<0.0001) and, importantly, it was independent of local culture.

Highly significant differences were found between sampling sites (χ 2 = 90.42, df = 38, p < 0.0001) and locations (χ 2 = 55.05, df = 18, p < 0.0001).

For FiO 2 , the increase at onset was highly significant (estimate = +0.33, 95% CI: 0.20–0.46, p < 0.0001), and the decrease post-intervention did not remain statistically significant (estimate = −0.19, 95% CI: −0.45–0.07, p = 0.10).

A full factorial ANOVA revealed that all four factors were highly significant in their impact on children's understanding of complex sentences ( p ≤ 0.0001).

Paired T-test analysis revealed extremely significant differences between the two groups in both diagnostic time and diagnostic costs ( P < 0.0001).

2 A, treatment with the IC50 concentrations of Aurelia aurita (18 μg/mL), Rhopilema nomadica (25 μg/mL), and Anemonia sulcata (3269 μg/mL) venoms resulted in a highly significant increase in the total apoptosis percentage compared to their respective untreated control groups (p < 0.0001).

The differences between species richness in NW and RB were highly significant ( P < 0.0001).