“might be significant”

The finding in a previous meta-analysis of ART adherence that stronger effects were more common in trials that required suboptimal adherence as an eligibility criterion [ 69 ] suggests that the efficacy of TRAC in improving medication use might be significant and greater were it focused on participants with the more serious adherence issues.

The results showed that there might be significant publication bias in DCR, and there were missing studies in all four outcomes with the trim-and-fill method.

Even though we did not measure this, which is a limitation in our study, our data do not suggest the presence of cytosolic DNA in amounts sufficient to lead to STING-mediated inflammation that might be significant for neuronal death.

First, depending on the degree of tissue connectivity, there might be significant movement of individual cells across the illumination boundaries, causing spread and dilution of activated cells within the tissue.

The data for the high frequency component’s power of the HRV and the RMSSD might be significant, but its decreasing course behaves differently than research and literature shows.

On the other hand, there might be significant changes in metabolism for the same cancer cells surviving in its changing microenvironment during tumorigenesis [ 83 ] and metastasis [ 84 ].

Depending on the software used, this may result less computational efficiency, which might be significant in large-scale datasets [ 26 ].

While the initial costs of replicating these findings might be significant, the long-term benefits of more effective treatment and potential medical care savings can be well justified.

Recently, the WHO has detected that the cytodifferentiation of SOT and mutations of Ameloblastin (AMBN) are related to NOTCH receptors and their ligands which indicates that this gene might be significant in the development of this neoplasm.[ 1 , 4 ] SOT usually appears as solitary, slow-growing, asymptomatic, or painful intraosseous lesion with bony expansion mostly affecting the tooth-bearing parts of the jaws, characterized by tooth mobility.

indicated that abnormal expression of methylation-associated enzymes such as DNMT3A and DNMT3B might be significant diagnostic tools rather than indicators of ITP activity [ 30 ]; Another study suggested an important role for DNMT3B rs2424913 Single-nucleotide polymorphisms (SNPs) in altering methylation phenotype and contributing to the pathogenesis of chronic ITP [ 31 ]; Aberrant methylation-related genes such as CD70 have also been involved in ITP, elevated expression of CD70 might be caused by its hypomethylated promoter region and can facilitate the survival of T and B lymphocytes, promote apoptosis of platelets, and enhance secretion of IFN-γ, finally accelerating the progress of ITP [ 32 ].

Additionally, transcriptome screening revealed that the coagulation cascade and complement pathways, along with the receptor C5aR1, might be significant mediators of sepsis-induced WMI.

Given their risk correlations with childhood ALL in boys, this finding might be significant [ 50 ].

Another explanation might be significant positive correlation between packing density and total negative mean curvature, which was also shown in our study.

97 Prior studies have proposed that there might be significant geographical differences in the prevalence and incidence of dementia.

Despite the risks, the potential benefits of ‘leading the pack’ on AI adoption might be significant.

Use of Standardised Drug Grouping in Detecting Signals of DDIs Earlier studies using disproportionality analysis to investigate DDIs where potential class effects might be significant have typically conducted separate analyses for individual drugs.

We acknowledge that most studies will be observational studies and there might be significant heterogeneity in the definitions of lower CRRT dose-intensity and reporting of outcomes.

Moreover, the severity of OA and contextual factors might be significant considerations to guide future interventions.

(5) The costs of oral health prevention (e.g., materials and dental hygienist visits) might be significant, and usually fall to patients who, in many cases, cannot afford it.

It might be significant that our analyses are identifying cell signaling intrinsic to the granulomatous lymph node, rather than specifically relating the patient’s overall inflammatory status.

This phenomenon suggested that there might be significant interactions between Pue and NR-CDs, resulting in a huge change in the microstructure of the hydrogel.

Some of the large effects might be significant; for example, Figure 2C We have now added Benjamini-Hochberg multiple-testing adjusted p-values in the text each time we present nominal p-values.

This might be significant from a clinical perspective: a low false negative rate reduces the risk of underestimating more aggressive tumors, facilitating a more cautious follow-up and a timely therapeutic approach.

Noted that the discrepancy in high-frequency region might be significant.

Even in cases where there are organic causes, depression, anxiety related to performance, and other sexual disorders might be significant contributing factors ( 10 ).