“might be significant”

A third possible diversification pathway is proposed, where neither P167S nor D240G were selected in the first stage of the process, and where neutral drift might be significant in the initial steps.

This might be significant for the clinical management of LADA in therapeutic efforts aimed at β-cell protection.

Alternatively, a pathway that overrides the p53-p21 inhibitory loop without affecting the pro-apoptotic function of p53 might be significant in driving apoptosis following DNA damage.

This might be significant in the context of ischemia, in which intracellular Ca 2+ overload has been implicated as a primary mechanism of neuronal injury [ 35 – 37 ].

We could also speculate that the constitutive activation of antigen presentation pathways might be significant in modulating T cells responses and be responsible for their heterogeneity in various cancers; this may explain the immunogenicity of some melanomas compared with other melanomas [ 43 ] and may become a tool to stratify cancer patients to be treated with T cell-directed vaccines.

In contrast, individual spiny cell axons mostly contact the proximal, medial or distal parts of the dendritic tree of other spiny neurons [3] , [6] , [23] – [28] , [37] , so here delay might be significant.

[ 9 ] because differences in sequence accuracies between the two strategies might be significant.

This residual labeling suggests gluconeogenesis might be significant in this mutant when grown on glycerol.

This information supports the supposition that serum GGT might be significant as a marker of oxidative stress.

We were particularly interested in seeing if there might be significant differences among different surrogate-normal groups.

An affinity-capture approach, described in Materials and Methods , was used in attempts to identify other 14-3-3 binding proteins in polarized, aldosterone-treated mCCD epithelia that might be significant in ENaC traffic regulation.

However, based on the assumption that a gene distance of up to five genes might be significant fourteen and three additional pairs could be described for S. cellulosum and M. xanthus , respectively.

There are always certain kinds of defect and lattice stress in nanowires, especially for those fabricated by the electrochemical method [ 26 , 27 ], and the surface defect and stress will increase substantially with decreasing nanowire diameter, which might be significant in determining the thermal behavior of nanowires.

In addition, it might be significant that the shortened and widened limb shape of Talpid3 mutant chick embryos looks similar to Boehm et al.'s computer predictions of limb buds lacking directional cell movements.

It has been suggested that LanCL1 might be significant for neurodegenerative diseases and in cellular signaling and differentiation [ 38 ].

Although in the majority of cases foreign bodies can be relatively easily removed, in some cases there might be significant difficulty in removal of a foreign body requiring the use of unusual equipments such as Amplatz dilators or even nephroscopes for the retrieval of screws as well as magnetic retrievers for galvanic objects [ 10 ].

A trend for a diagnosis × DAT1 10/6 ( p uncorrected <0.10) suggested that this effect might be significant only in the ADHD-CT group ( p corrected <0.05; p uncorrected =0.002; control group: p uncorrected >0.10).

Based on Rogers [ 9 ], communication among users might be significant in the innovation-decision process for two reasons: 1) in the knowledge stage, it assists the characterization of the communication behavior of an adoption unit, and 2) in the confirmation stage, it helps the adoption unit to become aware of a need inducing it to look for information about an innovation to fulfill that need.

Such suppression might be significant at the level of the olfactory bulb due to the high convergence of ∼1,000 ORNs onto a single glomerulus and the high “set point” of basal activity of second order neurons in the olfactory bulb in vivo in awake behaving mice ( Rinberg et al., 2006 ).

Thus, while the mouse KO screen did not directly identify novel targets for lowering Aβ, it did suggest a limited number of biochemical pathways that might be significant for regulation of brain Aβ levels in vivo , and that gene ablations causing a robust effect on brain Aβ are rare.

However, in several recent reports, it has been shown that the occurrence of mismatch repair ( MMR ) gene mutations at an early stage might be significant in tumourigenesis through KRAS mutation in MSI-H CRC.

School nurses are viewed as professionals who might be significant actors in the promotion of youth health.

Although there might be significant differences across disciplines (Kousha and Thelwall 2008 ), GS does appear to offer a more complete insight into the scientific literature.

Will the new polyethylene be better in the future? Improvements in the PE manufacturing processes might be significant in the next few years according to the works of Triclot et al.

To investigate genes that might be significant in the co-occurrence of BC and BII, the central genes for the overlapping DEGs were pinpointed with the aid of CytoHubba.