Predictive and Prognostic Value of Oncogene Mutations and Microsatellite Instability in Locally-Advanced Rectal Cancer Treated with Neoadjuvant Radiation-Based Therapy: A Systematic Review and Meta-Analysis.

Cancers (Basel) · 2023 · PMC10001009 · PMID 36900260

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

only marginally significantp = 0.06so close (0.05 < p ≤ 0.1)

An analysis stratified by cetuximab use confirmed previous findings: the risk of not achieving pCR was 2.17 (95% CI: 1.41–3.33) in patients not treated with cetuximab compared to 0.89 (95% CI: 0.39–2.05) in patients treated with cetuximab; however, this difference was only marginally significant ( p = 0.06). 3.2.2.

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a nonsignificant trendno p-value reported

It should be noted, however, that all studies consistently reported a nonsignificant trend toward a lower risk of non-response to therapy for carriers of tumor MSI-H status. 3.3.2.

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