Changes in Bone Metabolism in Patients with Rheumatoid Arthritis during Tumor Necrosis Factor Inhibitor Therapy.

J Clin Med · 2023 · PMC10003627 · PMID 36902687

Europe PMC DOI

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failed to reach statistical significanceno p-value reported

However, in their cohort, the improvements in BMD in the lumbar spine and femoral neck, as well as the corresponding T scores, failed to reach statistical significance.

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a decreasing trendno p-value reported

Upon completion of 12-month therapy, a significant increase ( p < 0.001) in P1NP was observed relative to b-CTX, with mean total calcium and phosphorus values following a decreasing trend, while vitamin D levels increased.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.