Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer's Disease Model Mice and the SH-SY5Y Neuronal Cell Line.

Int J Mol Sci · 2023 · PMC10003662 · PMID 36902113

Europe PMC DOI

hedged sentences

0.0728

closest p · 1.5× alpha

0.0847

boldest claim

The sentences

trending towards significancep = 0.0728so close (0.05 < p ≤ 0.1)

Distance travelled, rearing and digging were lower in HFD-P compared to HFD-C, trending towards significance for digging at 12 weeks (−54.1%, p = 0.0728).

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a trend toward significancep = 0.0847so close (0.05 < p ≤ 0.1)

In the open field test (OFT, Figure 1 Biii), no significant between-group differences were observed in total distance travelled, time in the arena centre nor the frequency of rearing, digging or grooming over the course of the study (although Chow-P results were universally higher than Chow-C after 24 weeks supplementation with a trend toward significance for digging: 84.8%, p = 0.0847).

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