Peripubertal Alterations of Leptin Levels in Patients with Autism Spectrum Disorder and Elevated or Normal Body Weight.

Notably, there were no significant differences, either pre- or post-puberty, in leptin levels between the two groups of patients with overweightness/obesity (ASD+/Ob+ and ASD−/Ob+) or between the two groups with normal body weight (ASD+/Ob− and ASD−/Ob−) ( Figure 2 and Figure 3 ), although the comparison of non-ASD and ASD lean pre-pubertal children revealed a distinct trend toward significance ( p = 0.15, higher leptin levels in the ASD+/Ob− group than in the ASD−/Ob− group) ( Figure 2 ). 2.3.

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There were no significant differences in leptin levels either before or after puberty between ASD+/Ob+ and ASD−/Ob+ or between ASD+/Ob− and ASD−/Ob−, although there was a strong trend toward significance for higher pre-pubertal leptin levels in ASD+/Ob− than in ASD−/Ob−.

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