Transcriptional analysis links B cells and TERT expression to favorable prognosis in head and neck cancer.

PNAS Nexus · 2023 · PMC10003760 · PMID 36909826

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0650

boldest claim

The sentences

barely significantP = 0.05actually significant

With the exception of MAGEA3 that showed a barely significant P -value ( P = 0.05), no other conserved tumor antigen reached significance.

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a strong trendP = 0.06so close (0.05 < p ≤ 0.1)

However, in a multivariable Cox proportional hazard model after adjustment for sex, age, stage, HPV status, and TMB as clinical variables, only B cell infiltrate was found to be an independent marker of increased PFS ( P = 0.02), with a strong trend for TERT expression ( P = 0.06) (Table 1 ).

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a near significant trendP = 0.065so close (0.05 < p ≤ 0.1)

When examined by tumor stages (grouping stage I–II and stage III–IV, respectively the B high /TERT high signature showed a significant difference in early-stage group ( P = 0.024), and a near significant trend in the late-stage group ( P = 0.065) (Fig.

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