While only lineage-cKit+ (LK) cells displayed a significant decrease, more primitive progenitors, such as lineage-Sca1 +cKit + (LSK) cells, multipotent progenitors (MPP), and SLAM LSK, showed a trend of reduction.
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Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone.
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