The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.

Oncogene · 2023 · PMC10005955 · PMID 36693952

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a strong trendno p-value reported

A similar result was obtained in MFM-223 cells, with rescue by shRNA-resistant NRBP1 being P-Rex1-dependent for Rac1, and a strong trend for P-Rex1 dependency for Cdc42 (Supplementary Fig. 4C, D ).

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