The extracellular microenvironment in immune dysregulation and inflammation in retinal disorders.

Front Immunol · 2023 · PMC10014728 · PMID 36936905

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failed to reach statistical significanceno p-value reported

Additionally, mRNA expression of complement genes C5 and MCP is significantly upregulated in DHRD/ML cells and CFB was also shown to be elevated but failed to reach statistical significance ( 183 ). 7.2 Sorsby fundus dystrophy DHRD/ML not only shares striking phenotypic similarities with AMD but also with the seemingly unrelated SFD.

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highly significantno p-value reported

Both the highly significant enrichment of complement genes and the fact that several complement components have been found in drusen from AMD patient donor eyes ( 196 – 198 ) suggest an important role of complement dysregulation in AMD pathobiology.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.