A recently updated systematic review and meta-analysis showed a negative trend between sperm DFI values and the live birth rate in the case of IVF, although it was not statistically significant (RR = 0.48; 0.22–1.02; I 2 = 79) [ 15 ].
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Machine learning-based clustering to identify the combined effect of the DNA fragmentation index and conventional semen parameters on in vitro fertilization outcomes.
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The results showed a decreasing trend in the live birth, clinical pregnancy, and β -hCG positivity rates with increasing sperm DFI values.