The I148M <i>PNPLA3</i> variant mitigates niacin beneficial effects: How the genetic screening in non-alcoholic fatty liver disease patients gains value.

We found that dietary niacin showed a trend of reduction in patients carrying the PNPLA3 at-risk G allele and BMI ≥ 30 kg/m 2 ( Figure 1E ) whereas by stratifying patients according to the presence of severe steatosis the lower levels of niacin in subjects with the PNPLA3 CG/GG mutation didn’t vary across BMI ( Figure 1F ).

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